Our Experience
As a biology team leader for drug discovery programs, Neuroservice provides solution to identify how the tested drug/compound affects physiologically and therapeutically relevant endpoint(s).
13 BRAIN REGIONS
Cortex - 13 Studies
Hippocampus - 120+ studies
Striatum - 17 Studies
Spinal Cord - 13 Studies
DRG - 10 Studies
Global Pallidus - 9 Studies
Cerebellum - 9 Studies
Habenula - 6 Studies
Amygdala - 3 Studies
Raphe Nucleus - 2 Studies
Nucleus acumbens - 1 Study
VTA - 1 Study
Thalamus - 1 Study
Intrinsic excitability of neurons
Synaptic transmission between neurons
Synaptic plasticity
Intrisic excitability of networks
Voltage-gated ion channels
Ligand-gated ion channels
Intrisic excitability of neurons
Spontaneous action potential firing rate
resting membrane potential (Vm)
Input resistance (Rm)
Evoked action potential threshold (rheobase)
After hyperpolarizing potential (AHP)
Synaptic transmission between neurons
Field excitatory postsynaptic potentials (fEPSPs)
Evoked excitatory postsynaptic currents (EPSCs)
Evoked inhibitory postsynaptic currents (IPSCs)
Miniature spontaneous excitatory postsynaptic currents (mEPSCs)
Miniature spontaneous inhibitory postsynaptic currents (mIPSCs)
Synaptic Plasticity
Long-term potentiation (LTP)
Long-term depression (LTD)
Chemical LTD
Intrisic excitability of networks
Population spikes (pop spikes)
Epileptiform disharges (EDs)
Voltage-gated ion channels
Na currents
K currents
Ca currents
Ligand-gated ion channels
Glutamate receptors: AMPA
Glutamate receptors: NMDA
GABAA receptors
Nicotinic receptors
We perform our recording according to state-of-the-art protocols based on our two technical platforms, Patch-Clamp & Multi Electrode Array.