Custom Analysis

Patch Clamp – Action Potential Analysis

Presented  Calculation

RMP:  Sweep 1
Rm:  Mean of sweep 1 and 3
Spike threshold:  At rheobase
Spike amplitude:  At rheobase
Half-width:  At rheobase
Decay-time:  At rheobase
Firing:  All sweeps
Latency:  All sweeps (minimal is plotted)
First ISI:  All sweeps

Not Shown

Last ISI + Adaptation:  All sweeps
AHP fast:  At Rheobase
AHP slow:  All sweeps

Patch Clamp – Evoked EPSC Analysis

 

 

Amplitude: synaptic strength

Area: charge transfer

Rise time: kinetics of channel activation

Decay time: kinetics of channel inactivation

Paired-pulse ratio: short-term plasticity

(amplitude EPSC2/EPSC1)

 

Patch Clamp – Miniature EPSC Analysis

 

 

Amplitude: quantal size

Area: charge transfer

Rise time: kinetics of channel activation

Decay time: kinetics of channel inactivation

Frequency: presynaptic release characteristics