Our experience

As a biology team leader for drug discovery programs, Neuroservice provides solution to identify how the tested drug/compound affects physiologically and therapeutically relevant endpoint(s).







13
BRAIN
REGIONS

</br></br></br></br></br></br>13 </br>BRAIN </br>REGIONS
Cortex - 13 Studies Hippocampus - 120+ studies Striatum - 17 Studies Spinal Cord - 13 Studies DRG - 10 Studies Global Pallidus - 9 Studies Cerebellum - 9 Studies Habenula - 6 Studies Amygdala - 3 Studies Raphe Nucleus - 2 Studies Nucleus acumbens - 1 Study VTA - 1 Study Thalamus - 1 Study

Cortex - 13 Studies

Hippocampus - 120+ studies

Striatum - 17 Studies

Spinal Cord - 13 Studies

DRG - 10 Studies

Global Pallidus - 9 Studies

Cerebellum - 9 Studies

Habenula - 6 Studies

Amygdala - 3 Studies

Raphe Nucleus - 2 Studies

Nucleus acumbens - 1 Study

VTA - 1 Study

Thalamus - 1 Study

Intrisic excitability
of neurons
Synaptic transmission between neurons
Synaptic plasticity
Intrisic excitability
of networks
Voltage-gated
ion channels
Ligand-gated ion
channels

Intrisic excitability
of neurons

Spontaneous action potential firing rate
resting membrane potential (Vm)
Input resistance (Rm)
Evoked action potential threshold (rheobase)
After hyperpolarizing potential (AHP)

Synaptic transmission between neurons

Field excitatory postsynaptic potentials (fEPSPs)
Evoked excitatory postsynaptic currents (EPSCs)
Evoked inhibitory postsynaptic currents (IPSCs)
Miniature spontaneous excitatory postsynaptic currents (mEPSCs)
Miniature spontaneous inhibitory postsynaptic currents (mIPSCs)

Synaptic Plasticity

Long-term potentiation (LTP)
Long-term depression (LTD)
Chemical LTD

Intrisic excitability of networks

Population spikes (pop spikes)
Epileptiform disharges (EDs)

Voltage-gated ion channels

Na currents
K currents
Ca currents

Ligand-gated ion channels

Glutamate receptors: AMPA
Glutamate receptors: NMDA
GABAA receptors
Nicotinic receptors

We perform our recording according to state-of-the-art protocols based on our two technical platforms, Patch-Clamp & Multi Electrode Array.