Mechanism Of Action

NEUROSERVICE provides a wide range of electrophysiological assays to validate target(s) and to understand the Mechanism(s) Of Action of lead compounds.

• Molecular effects under real physiological conditions
• Dose-Response or Dose-Inhibition Protocols
• Characterization of Allosteric Modulators
• Drug-drug interactions
• Effects on Synaptic Transmission
• Effects on Synaptic Plasticity

The recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi- Electrode Array (MEA) and the Patch-Clamp techniques and enable the investigation of Mechanism Of Action from a neuronal network down to a single channel.

NEUROSERVICE strives to meet each customer’s needs with assays from its portfolio or with individually customized protocol