Lead Selection & Optimization
NEUROSERVICE provides a wide range of electrophysiological assays to support the lead compound and optimization during the R&D phases of CNS and Pain programs.
- Validation of multiple series of compounds with real physiological data.
- Determination of Dose-Response or Dose-Inhibition profiles for reference & test compounds.
- Mid-throughput Screening of series of compounds under physiological conditions.
- Precise determination of lead pharmacological profiles for selection and optimization.
The recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.