Toxicology
SAFETY & TOXICOLOGY PROFILING FOR THE CENTRAL NERVOUS SYSTEM
NEUROSERVICE provides Drug Discovery, Agrochemistry, Food & Cosmetics industries with high-quality and very sensitive assays to investigate the acute safety or toxicity of compounds in the Central Nervous System.
NEUROSERVICE's assays allow to investigate any acute toxicity on the main CNS functions (neuronal firing, synaptic transmission, synaptic plasticity, short- or long-term memory).
In addition, chronic effects on the main CNS functions can be investigated in brain slices prepared from rodents dosed with compounds for 1-2 weeks.
NEUROSERVICE offers a "NEUROTOX PACKAGE" to address the main CNS toxicological issues:
Evaluation of the absence of effects of 1 compound (at 2 concentrations) on 5 main CNS functions:
RECORDINGS:
- Spontaneous neuronal firing
- Basal synaptic transmission
- Short-Term synaptic plasticity (Paired-Pulse Facilitation)
- Potentiation of Long-Term synaptic plasticity (Long-Term Potentiation)
- Inhibition of Long-Term synaptic plasticity (Long-Term Depression)
Any effect detected during the recordings ► further investigation proposal
WITH:
- Multi-Electrode Array recordings
- Mice or rats
- Acute Hippocampal slices
- 3 slices/concentration
1 week to get the results
The NEUROTOX PACKAGE:
►The right & the fast answer
