| Toxic effects
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Target
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Pharm. Ref.
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Biology
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Bibliography |
Code
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Name
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PDF |
Interaction with fast sodium channels or AP |
Sodium channels |
TTX and lidocaine |
Action Potentials propagation. |
- Egert U, Heck D, Aertsen A (2002). Exp Brain Res 142:268-274.
- Smith SL, Otis TS (2003). J Neurosci 23:367-372.
- Stett A, Egert U, Guenther E, Hofmann F, Meyer T, Nisch W, Haemmerle H (2003). Anal Bioanal Chem 377:486-495.
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SAP-001 |
Spontaneous Action Potentials of Purkinje Neurons |
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Interaction with fast sodium channels or AP |
Sodium channels |
TTX |
Action Potentials propagation |
- Colmers WF, Lukowiak K, Pittman QJ (1988). J Neurosci 8:3827-3837.
- Devor, M. (2006), J. Pain, 7(1 Suppl 1), S31-S37
- King GL, Dingledine R, Giacchino JL, McNamara JO (1985). J Neurophysiol 54:1295-1304.
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SAP-002 |
Evoked Spikes in the CA3/CA1 region |
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Modification of excitatory/ inhibitory neurotransmission weight |
AMPA/kainate receptors |
Receptors NBQX/CNQX |
Glutamate-mediated neurotransmission |
- Goldstein JM, Litwin LC (1993). Mol Chem Neuropathol 18:145-152.
- Namba T, Morimoto K, Sato K, Yamada N, Kuroda S (1994). Brain Res 638:36-44.
- Sheardown MJ (1993). Stroke 24:I146-147; discussion I153-144.
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SST-001 |
Basal Synaptic Transmission (Schaeffer Collaterals stimulation) |
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Modification of short-term synaptic plasticity |
Presynaptic receptors (GPCR) |
Carbachol |
Short-term pre-synaptic plasticity |
- I wata N, Higuchi M, Saido TC (2005). Pharmacol Ther 108:129-148.
- Price CJ, Karayannis T, Pal BZ, Capogna M (2005). Neuropharmacology 49 Suppl 1:45-56.
- Zucker RS, Regehr WG (2002) Short-term synaptic plasticity. Annu Rev Physiol 64:355-405.
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SST-002 |
Paired-Pulse Facilitation in CA1 region |
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Interaction with long-lasting plasticity potentiation |
NMDA receptors |
D-AP5 / MK801 / memantine |
Long-term synaptic plasticity |
- Artola A, von Frijtag JC, Fermont PC, Gispen WH, Schrama LH, Kamal A, Spruijt BM (2006). Eur J Neurosci 23:261-272.
- Chen L, Miyamoto Y, Furuya K, Dai XN, Mori N, Sokabe M (2006). Neuropharmacology 51:659-670.
- Pastalkova E, Serrano P, Pinkhasova D, Wallace E, Fenton AA, Sacktor TC (2006). Science 313:1141-1144.
- Malenka, RC & Nicoll, RA (1999), Science, 285, 1870-1874.
- Rioult-Pedotti M-S, Friedman D and Donoghue JP (2006), Science, 290, 533-536.
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SST-003 |
Long-Term Potentiation in CA1 region (100 Hz protocol) |
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Interaction with long-lasting plasticity depression |
NMDA receptors |
D-AP5 |
Long-term synaptic plasticity |
- Artola A, von Frijtag JC, Fermont PC, Gispen WH, Schrama LH, Kamal A, Spruijt BM (2006). Eur J Neurosci 23:261-272.
- Kemp A, Manahan-Vaughan D (2007). Trends Neurosci 30:111-118.
- Yang J, Han H, Cao J, Li L, Xu L (2006). Hippocampus 16:431-436.
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SST-004 |
Long-Term Depression in CA1 region (1 Hz protocol) |
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Interaction with long-lasting plasticity potentiation |
GluR5-Containing Kainate receptors |
On going |
Long-Term synaptic plasticity |
- Bortolotto ZA, Lauri S, Isaac JT, Collingridge GL (2003). Philos Trans R Soc Lond B Biol Sci 358:657-666.
- Bortolotto ZA, Clarke VR, Delany CM, Parry MC, Smolders I, Vignes M, Ho KH, Miu P, Brinton BT, Fantaske R, Ogden A, Gates M, Ornstein PL, Lodge D, Bleakman D, Collingridge GL (1999). Nature 402:297-301.
- More JC, Nistico R, Dolman NP, Clarke VR, Alt AJ, Ogden AM, Buelens FP, Troop HM, Kelland EE, Pilato F, Bleakman D, Bortolotto ZA, Collingridge GL, Jane DE (2004). Neuropharmacology 47:46-64.
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SST-005 |
Long-Term Potentiation in CA3 region (100 Hz protocol) |
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Modification of CA1 neurons excitability/pro-convulsive properties |
NA |
Kainate & Carbamazepine |
CA1 pyramidal neurons spontaneous activity |
- Day IP, Goudie J, Nishiki K, Williams PD (1995). Toxicol Lett. Apr;76(3):239-43.
- Easter A, Bell ME, Damewood JR Jr, Redfern WS, Valentin JP, Winter MJ, Fonck C, Bialecki RA. (2009). Drug Discov Today.Sep;14(17-18):876-84. Jun 21. Review.
- Ketelaars SO, Gorter JA, van Vliet EA, Lopes da Silva FH, Wadman WJ. (2001). Neuroscience. 105(1):109-20.
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SAP-003 |
Characterization of pro- or anti-convulsive properties |
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