HOME > TESTING > PORTFOLIO > MEA

MEA (Multi-Electrode Array)

NEUROSERVICE offers standardized MEA tests enabling parallel and multi-site extra-cellular recordings within a single slice and providing an exceptional macroscopic view of neuronal networks.

The MEA recordings of NEUROSERVICE allow mid-throughput testing capabilities for compound screening and profiling.

Drug Development tests :

Code

Name

Target

Pharma. Ref.

Biology

PDF

P-001

Fast sodium channel inhibition

Sodium channels

Tetrodotoxin

Action Potential genesis and propagation

P-002

AMPA- ediated synaptic transmission

AMPA/Kainate receptors

NBQX

Glutamatergic synaptic transmission

P-003

NMDA receptors competitive antagonist

NMDA receptors

D-AP5

Long-Term Potentiation

P-004

GABA-A receptors - Network Excitability

GABA-A receptors

Bicuculline

Epileptiform activity

P-005

Neurosteroids / GABA-A receptors

GABA-A receptors

Ganaxolone

Allosteric modulation of GABA-A

P-006

Inhibition of phasic GABA-A receptors

Phasic GABA-A receptors

Gabazin (SR-95531)

GABA-A receptor-mediated fast synaptic transmission

P-007

DHPG - induced LTD

mGluR1 & mGluR5 receptors

DHPG

LTD induced by mGluR1/mGluR5 activation

P-008

AMPA/Kainate receptors-mediated excitotoxicity

AMPA/Kainate receptors

Kainate

Excitotoxicity

P-009

L-type calcium channels / Synaptic Transmission

L-type VDCC

Nifedipine

Modulation of synaptic transmission by VDCC

P-010

Cholinergic transmission - Alzheimer's disease

Acetylcholinesterase

Physostigmine (Eserine)

cholinergic modulation of glutamate neurotransmission

P-011

NMDA & Nicotinic receptors / Alzheimer's & Parkinson's diseases

NMDA & Nicotinic receptors

Memantine

Long-Term Potentiation / Memory

P-012

H3 Histamine receptor-dependent depression in Dentate Gyrus

H3 Histamine receptor

R-alpha-methylhistamine

Pre-synaptic H3 receptor

P-013

Histamine receptors mediated increase of CA1 pyramidal neurons firing

H1 and H2 Histamine receptors

Histamine

CA1 pyramidal neurons spontaneous activity

P-014

mGluR2-mediated depression of synaptic transmission at MPP synapses

mGluR2 receptors

DCG-IV

Pre-synaptic mGluR2 receptors

P-015

Dopamine-induced increase of synaptic transmission and plasticity

D1/D5 Dopamine receptors

SCH23390

Dopaminergic modulation of synaptic transmission

P-016

Model of 4-AP-induced epilepsy

K+ channel

Phenytoin / Carbamazepine

In vitro epilepsy model

P-017

Model of low-magnesium-induced epilepsy

NMDA receptor

Phenytoin / Carbamazepine

In vitro epilepsy model

P-018

Model of bicuculline-induced epilepsy

GABA-A receptor

Somatostatin

In vitro model of epilepsy

P-019

Model of cholinergic-induced epilepsy

GABA-A / M1muscarinic receptors

Diazepam

In vitro epilepsy model

Toxicological Tests :

Code

Name

Target

Pharma. Ref.

Biology

PDF

SAP-001

Spontaneous Action Potentials of Purkinje Neurons

Sodium channels

TTX and lidocaine

Action Potentials propagation

SAP-002

Evoked Spikes in the CA3/CA1 region

Sodium channels

TTX

Action Potentials propagation

SST-001

Basal Synaptic Transmission (Schaeffer Collaterals stimulation)

AMPA/kainate receptors

Receptors NBQX/CNQX

Glutamate-mediated neurotransmission

SST-002

Paired-Pulse Facilitation in CA1 region

Presynaptic receptors (GPCR)

Carbachol

Short-term pre-synaptic plasticity

SST-003

Long-Term Potentiation in CA1 region (100 Hz protocol)

NMDA receptors

D-AP5 / MK801 / memantine

Long-term synaptic plasticity

SST-004

Long-Term Depression in CA1 region (1 Hz protocol)

NMDA receptors

D-AP5

Long-term synaptic plasticity

SST-005

Long-Term Potentiation in CA3 region (100 Hz protocol)

GluR5-Containing Kainate receptors

On going

Long-Term synaptic plasticity