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Mechanism Of Action

 

NEUROSERVICE provides a wide range of electrophysiological assays to validate target(s) and to understand the Mechanism(s) Of Action of lead compounds.

  • Molecular effects under real physiological conditions
  • Dose-Response or Dose-Inhibition Protocols
  • Characterization of Allosteric Modulators
  • Drug-drug interactions
  • Effects on Synaptic Transmission
  • Effects on Synaptic Plasticity

The recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi- Electrode Array (MEA) and the Patch-Clamp techniques and enable the investigation of Mechanism Of Action from a neuronal network down to a single channel.

NEUROSERVICE strives to meet each customer’s needs with assays from its portfolio or with individually customized protocol

 

Table of protocols and structures which can be studied

Guarantee of technological platforms and high skilled expertise team

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