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Lead Selection & Optimization


NEUROSERVICE provides a wide range of electrophysiological assays to support the lead compound and optimization during the R&D phases of CNS and Pain programs.

  • Validation of multiple series of compounds with real physiological data.
  • Determination of Dose-Response or Dose-Inhibition profiles for reference & test compounds.
  • Mid-throughput Screening of series of compounds under physiological conditions.
  • Precise determination of lead pharmacological profiles for selection and optimization.

The recordings are performed in acute brain and spinal cord slices from rodents (mice or rats) with the Multi-Electrode Array (MEA) and Patch-Clamp techniques.

NEUROSERVICE strives to meet each customer’s needs with assays from its portfolio or with individually customized protocols.


Table of protocols and structures which can be studied

Guarantee of technological platforms and high skilled expertise team

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