epilepsy

More Americans Than Ever Have Epilepsy

A new Centers for Disease Control and Prevention (CDC) study published in August 2017 reported national and state estimates of the numbers of adults and children with active epilepsy in the US in 2015. In an expert interview, Dr. Privitera, past president of the AES, 2016, discusses the implications of the latest data including the […]

epilepsy

What is the precise action of your anti-epileptic drug on neuronal networks and on neurotransmission?

Electrophysiology changes the game     Demonstrating that a potential anti-epilepsy compound has the expected effect requires different stages of analysis, at the neuronal network but also at the cellular level. Two electrophysiological techniques, the Multi-Electrode Array and the patch-clamp, greatly aid in these analyses in a highly complementary fashion. Explanations by Chun-Yao LEE and […]

cognition

Cognition studies: your lead compound works in vivo but its mechanism of action (MOA) remains unclear?

    Bruno Buisson, founder, general manager & chief scientist at Neuroservice, explains how electrophysiology can illuminate pharmacological compound profile, providing a clearer understanding of mechanism of action, with an in vitro approach for cognition mechanisms on a true neuronal network.     COGNITION STUDIES: INSUFFICIENT INFORMATION ON MECHANISM OF ACTION OF YOUR COMPOUND ? […]