epilepsy

What is the precise action of your anti-epileptic drug on neuronal networks and on neurotransmission?

Electrophysiology changes the game     Demonstrating that a potential anti-epilepsy compound has the expected effect requires different stages of analysis, at the neuronal network but also at the cellular level. Two electrophysiological techniques, the Multi-Electrode Array and the patch-clamp, greatly aid in these analyses in a highly complementary fashion. Explanations by Chun-Yao LEE and […]

cognition

Cognition studies: your lead compound works in vivo but its mechanism of action (MOA) remains unclear?

    Bruno Buisson, founder, general manager & chief scientist at Neuroservice, explains how electrophysiology can illuminate pharmacological compound profile, providing a clearer understanding of mechanism of action, with an in vitro approach for cognition mechanisms on a true neuronal network.     COGNITION STUDIES: INSUFFICIENT INFORMATION ON MECHANISM OF ACTION OF YOUR COMPOUND ? […]

Neuromuscular junctions - SMA mouse - Thierry Bordet - NSblog- 2

Olesoxime, a first hope for Spinal Muscular Atrophy (SMA) patients

About the author  Thierry Bordet has more than 15 years of experience leading drug discovery efforts from preclinical research to proof-of-concept across biotech and academic settings. At Trophos, Thierry led various drug discovery programs for motor neuron disorders which culminated in the identification of Olesoxime, the first treatment for Spinal Muscular Atrophies (SMA). He has […]